Exiting the ER: what we know and what we don’t

Exiting the ER: what we know and what we don’t

Highlights • Recent advances in our understanding of the biogenesis of COPII-dependent carriers at the ER are discussed. • Exit of large cargoes and its relevance for genetic diseases involving components of the early secretory pathway is discussed. • Some unresolved issues that future work should a...

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Veröffentlicht in:Trends in cell biology 2014-01, Vol.24 (1), p.9-18
Hauptverfasser: Venditti, Rossella, Wilson, Cathal, De Matteis, Maria Antonietta
Format: Artikel
Sprache:eng
Schlagworte:
Animals
COP-Coated Vesicles - metabolism
COPII coat
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum - ultrastructure
ER export
ER-derived carriers
genetic disease of membrane trafficking
Humans
Organ Specificity
Pathology
Protein Sorting Signals
Protein Transport
Transport Vesicles - metabolism
Transport Vesicles - ultrastructure
Vesicular Transport Proteins - metabolism
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Beschreibung
Zusammenfassung:Highlights • Recent advances in our understanding of the biogenesis of COPII-dependent carriers at the ER are discussed. • Exit of large cargoes and its relevance for genetic diseases involving components of the early secretory pathway is discussed. • Some unresolved issues that future work should address to better understand the physiology of COPII-mediated transport are highlighted.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.08.005