Twist1 and Y-box-binding protein-1 are potential prognostic factors in bladder cancer

Abstract Objective To investigate the expression and possible roles of Twist1 and Y-box-binding protein-1 (YB-1) in bladder cancer tissue. Twist1 belongs to the family of basic helix-loop-helix transcription factors. A functional link between Twist1 and YB-1 has recently been determined to play an i...

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Veröffentlicht in:	Urologic oncology 2014, Vol.32 (1), p.31.e1-31.e7
Hauptverfasser:	Song, Yoo Hyun, PhD, MD, Shiota, Masaki, PhD, MD, Yokomizo, Akira, PhD, MD, Uchiumi, Takeshi, PhD, MD, Kiyoshima, Keijiro, PhD, MD, Kuroiwa, Kentaro, PhD, MD, Oda, Yoshinao, PhD, MD, Naito, Seiji, PhD, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bladder cancer Cell Line, Tumor Disease Progression Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Invasiveness Nuclear Proteins - metabolism Treatment Outcome Twist-Related Protein 1 - metabolism Twist1 Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - mortality Urology Y-Box-Binding Protein 1 - metabolism YB-1
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Zusammenfassung:	Abstract Objective To investigate the expression and possible roles of Twist1 and Y-box-binding protein-1 (YB-1) in bladder cancer tissue. Twist1 belongs to the family of basic helix-loop-helix transcription factors. A functional link between Twist1 and YB-1 has recently been determined to play an important role in bladder cancer cell lines. Materials and methods Frozen samples from 75 patients with bladder cancer were analyzed by quantitative real-time polymerase chain reaction (PCR). Formalin-fixed and paraffin-embedded tissues from 53 patients with bladder cancer were examined by immunohistochemistry. Results Twist1 transcript levels were positively correlated with YB-1 transcript levels (coefficient of correlation = 0.42, P
ISSN:	1078-1439 1873-2496
DOI:	10.1016/j.urolonc.2012.11.003