Copper-Catalyzed Allylation of α,α-Difluoro-Substituted Organozinc Reagents

Copper-Catalyzed Allylation of α,α-Difluoro-Substituted Organozinc Reagents

A method for the coupling of organozinc reagents, difluorocarbene, and allylic electrophiles is described. The reaction involves insertion of difluorocarbene into the carbon–zinc bond followed by copper-catalyzed allylic substitution.

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Veröffentlicht in:Journal of organic chemistry 2014-01, Vol.79 (2), p.818-822
Hauptverfasser: Zemtsov, Artem A, Kondratyev, Nikolay S, Levin, Vitalij V, Struchkova, Marina I, Dilman, Alexander D
Format: Artikel
Sprache:eng
Schlagworte:
Allyl Compounds - chemistry
Catalysis
Copper - chemistry
Hydrocarbons, Fluorinated - chemical synthesis
Hydrocarbons, Fluorinated - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Zinc - chemistry
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Zusammenfassung:A method for the coupling of organozinc reagents, difluorocarbene, and allylic electrophiles is described. The reaction involves insertion of difluorocarbene into the carbon–zinc bond followed by copper-catalyzed allylic substitution.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo4024705