Selective and Sensitive Superoxide Detection with a New Diselenide-Based Molecular Probe in Living Breast Cancer Cells

A diselenide-based BODIPY probe was prepared; it was found to be sensitive and selective for superoxide in giving [-Se(O)Se(O)-] oxidation. Probing was reversible through the use of biothiols; 77Se NMR and other types of spectroscopy were employed. Practical medicinal utility was demonstrated in MCF...

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Veröffentlicht in:	Organic letters 2014-01, Vol.16 (2), p.410-412
Hauptverfasser:	Manjare, Sudesh T, Kim, Sungsoo, Heo, Won Do, Churchill, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Boron Compounds - chemical synthesis Boron Compounds - chemistry Breast Neoplasms Female Humans MCF-7 Cells Molecular Probes Molecular Structure Nuclear Magnetic Resonance, Biomolecular Organoselenium Compounds - chemical synthesis Organoselenium Compounds - chemistry Oxidation-Reduction Superoxides - analysis Tumor Cells, Cultured
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Zusammenfassung:	A diselenide-based BODIPY probe was prepared; it was found to be sensitive and selective for superoxide in giving [-Se(O)Se(O)-] oxidation. Probing was reversible through the use of biothiols; 77Se NMR and other types of spectroscopy were employed. Practical medicinal utility was demonstrated in MCF-7/ADR cancer cells.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol4033013