Proteomic signatures of angiogenesis in androgen-independent prostate cancer

INTRODUCTION The observation that angiogenesis, the process of new blood vessel formation, in healthy prostate and early prostate cancer is androgen‐dependent gave rise to significant questions on how hypervascularization and increased angiogenesis is also achieved at the molecular level in advanced androgen‐independent prostate cancer. The exact paracrine molecular network that is hardwired into the proteome of the endothelial and cancer subpopulations participating in this process remains partially understood. METHODS Here, we interrogated the signaling pathways and the molecular functional signatures across the proteome of endothelial cells after interacting with various secretomes produced by androgen‐dependent and ‐independent prostate cancer cells. RESULTS We found the significant overexpression (P