Copper-Catalyzed Aerobic Oxidative Coupling of Aromatic Alcohols and Acetonitrile to β‑Ketonitriles

A practical, convenient, and cheap copper-catalyzed aerobic oxidative coupling of aromatic alcohols and acetonitrile to β-ketonitriles has been developed. The green C–C bond formation involving the loss of two hydrogen atoms from the corresponding two carbons, respectively, unlocks opportunities for...

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Veröffentlicht in:	Organic letters 2014-01, Vol.16 (2), p.350-353
Hauptverfasser:	Shen, Jiaxuan, Yang, Dejun, Liu, Yuxiao, Qin, Shuangshuang, Zhang, Jingwu, Sun, Jiangkai, Liu, Chunhui, Liu, Chaoyang, Zhao, Xiaomei, Chu, Changhu, Liu, Renhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - chemistry Catalysis Copper - chemistry Hydrogen Ketones - chemical synthesis Ketones - chemistry Molecular Structure Nitriles - chemical synthesis Nitriles - chemistry Oxidative Coupling
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Beschreibung
Zusammenfassung:	A practical, convenient, and cheap copper-catalyzed aerobic oxidative coupling of aromatic alcohols and acetonitrile to β-ketonitriles has been developed. The green C–C bond formation involving the loss of two hydrogen atoms from the corresponding two carbons, respectively, unlocks opportunities for markedly different synthetic strategies.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol403555n