Pharmacological study of the one spike spherical neuron phenotype in Gymnotus omarorum

Highlights • Gymnotus shows one-spike neurons firing one-to-one after electric organ discharge. • A low-threshold potassium channel supports such a profile, causing long refractoriness. • These features subserve a dynamic sensory filter for streaming self-generated signals. • Differences with wave f...

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Veröffentlicht in:	Neuroscience 2014-01, Vol.258, p.347-354
Hauptverfasser:	Nogueira, J, Caputi, A.A
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Action Potentials - drug effects Action Potentials - physiology Animals Biological and medical sciences Cesium - pharmacology Chlorides - pharmacology Elapid Venoms - pharmacology electroreception Fundamental and applied biological sciences. Psychology Gymnotiformes - physiology In Vitro Techniques intrinsic properties low responsiveness window Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Transport Modulators - pharmacology Mesencephalon - drug effects Mesencephalon - physiology Neurology Neurons - drug effects Neurons - physiology onset neuron Patch-Clamp Techniques Potassium - metabolism Potassium Channel Blockers - pharmacology Potassium Channels - metabolism single spiking Tetraethylammonium - pharmacology time coding Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Gymnotus shows one-spike neurons firing one-to-one after electric organ discharge. • A low-threshold potassium channel supports such a profile, causing long refractoriness. • These features subserve a dynamic sensory filter for streaming self-generated signals. • Differences with wave fish suggest co-evolution of sensory and electromotor systems. • Similarities with the auditory neurons suggest a convergent evolution.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.11.021