Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus
Highlights • The majority of the GHRH perikarya form juxtapositions with enkephalinergic fibers. • Endorphinergic-GHRH associations are much less frequent. • Dynorphinergic-GHRH juxtapositions are extremely rare in the human hypothalamus. • Thus endorphins/dynorphins play a minor role in the regulat...
Gespeichert in:
| Veröffentlicht in: | Neuroscience 2014-01, Vol.258, p.238-245 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 245 |
|---|---|
| container_issue | |
| container_start_page | 238 |
| container_title | Neuroscience |
| container_volume | 258 |
| creator | Olsen, J Peroski, M Kiczek, M Grignol, G Merchenthaler, I Dudas, B |
| description | Highlights • The majority of the GHRH perikarya form juxtapositions with enkephalinergic fibers. • Endorphinergic-GHRH associations are much less frequent. • Dynorphinergic-GHRH juxtapositions are extremely rare in the human hypothalamus. • Thus endorphins/dynorphins play a minor role in the regulation of growth via GHRH. • Enkephalinergic-GHRH contacts may represent the impact of opiates on growth. |
| doi_str_mv | 10.1016/j.neuroscience.2013.11.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490765667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0306452213009512</els_id><sourcerecordid>1490765667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-6b555eefee1d78642d86f58e71e13bf261504122f01d5b1b9280700658a6d0e53</originalsourceid><addsrcrecordid>eNqNksFu1DAQhiMEotvCK6AICYlLgseOnSwHpKoUqFSJA3C2HGey8ZLYi-1Q7QPw3jhsCogTvliyvn9m_P-TZc-BlEBAvNqXFmfvgjZoNZaUACsBSgLwINtAU7Oi5lX1MNsQRkRRcUrPsvMQ9iQdXrHH2RmtKNvWsN1kP25sNJOKmKsQnDYqGmdD3mK8Q7R5HDBH27kdWjeH3B3MgoZjiDiFXNnuF7Hz7i4O-eD85CwWHkdUwdjd_csqyM2p4DBPyubD8eDioEY1zeFJ9qhXY8Cn632RfXl3_fnqQ3H78f3N1eVtoSvBYyFazjlijwhd3YiKdo3oeYM1ILC2pwI4qYDSnkDHW2i3tCE1IYI3SnQEObvIXp7qHrz7NmOIcjJB4zgqi-l_EqotqQUXok7o6xOqk9PBYy8PPhnljxKIXGKQe_l3DHKJQQLIFEMSP1v7zO2E3W_pve8JeLECKmg19l5ZbcIfroGm4Uwk7u2Jw-TKd4Neru0641FH2Tnzf_O8-aeMHo01qfNXPGLYu9nb5LsEGagk8tOyOMveACNky4Gyn3DKxLU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490765667</pqid></control><display><type>article</type><title>Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Olsen, J ; Peroski, M ; Kiczek, M ; Grignol, G ; Merchenthaler, I ; Dudas, B</creator><creatorcontrib>Olsen, J ; Peroski, M ; Kiczek, M ; Grignol, G ; Merchenthaler, I ; Dudas, B</creatorcontrib><description>Highlights • The majority of the GHRH perikarya form juxtapositions with enkephalinergic fibers. • Endorphinergic-GHRH associations are much less frequent. • Dynorphinergic-GHRH juxtapositions are extremely rare in the human hypothalamus. • Thus endorphins/dynorphins play a minor role in the regulation of growth via GHRH. • Enkephalinergic-GHRH contacts may represent the impact of opiates on growth.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2013.11.011</identifier><identifier>PMID: 24239719</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Axons - metabolism ; beta-Endorphin - metabolism ; Biological and medical sciences ; dynorphin ; Dynorphins - metabolism ; endorphin ; enkephalin ; Enkephalin, Leucine - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; GHRH ; growth ; Growth Hormone-Releasing Hormone - metabolism ; Humans ; hypothalamus ; Hypothalamus - metabolism ; Immunohistochemistry ; Male ; Median Eminence - metabolism ; Neurology ; Neurons - metabolism ; Opioid Peptides - metabolism ; Pituitary Gland, Posterior - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2014-01, Vol.258, p.238-245</ispartof><rights>IBRO</rights><rights>2013 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-6b555eefee1d78642d86f58e71e13bf261504122f01d5b1b9280700658a6d0e53</citedby><cites>FETCH-LOGICAL-c465t-6b555eefee1d78642d86f58e71e13bf261504122f01d5b1b9280700658a6d0e53</cites><orcidid>0000-0002-0190-9975</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452213009512$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28188536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24239719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olsen, J</creatorcontrib><creatorcontrib>Peroski, M</creatorcontrib><creatorcontrib>Kiczek, M</creatorcontrib><creatorcontrib>Grignol, G</creatorcontrib><creatorcontrib>Merchenthaler, I</creatorcontrib><creatorcontrib>Dudas, B</creatorcontrib><title>Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • The majority of the GHRH perikarya form juxtapositions with enkephalinergic fibers. • Endorphinergic-GHRH associations are much less frequent. • Dynorphinergic-GHRH juxtapositions are extremely rare in the human hypothalamus. • Thus endorphins/dynorphins play a minor role in the regulation of growth via GHRH. • Enkephalinergic-GHRH contacts may represent the impact of opiates on growth.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Axons - metabolism</subject><subject>beta-Endorphin - metabolism</subject><subject>Biological and medical sciences</subject><subject>dynorphin</subject><subject>Dynorphins - metabolism</subject><subject>endorphin</subject><subject>enkephalin</subject><subject>Enkephalin, Leucine - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GHRH</subject><subject>growth</subject><subject>Growth Hormone-Releasing Hormone - metabolism</subject><subject>Humans</subject><subject>hypothalamus</subject><subject>Hypothalamus - metabolism</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Median Eminence - metabolism</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Opioid Peptides - metabolism</subject><subject>Pituitary Gland, Posterior - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEotvCK6AICYlLgseOnSwHpKoUqFSJA3C2HGey8ZLYi-1Q7QPw3jhsCogTvliyvn9m_P-TZc-BlEBAvNqXFmfvgjZoNZaUACsBSgLwINtAU7Oi5lX1MNsQRkRRcUrPsvMQ9iQdXrHH2RmtKNvWsN1kP25sNJOKmKsQnDYqGmdD3mK8Q7R5HDBH27kdWjeH3B3MgoZjiDiFXNnuF7Hz7i4O-eD85CwWHkdUwdjd_csqyM2p4DBPyubD8eDioEY1zeFJ9qhXY8Cn632RfXl3_fnqQ3H78f3N1eVtoSvBYyFazjlijwhd3YiKdo3oeYM1ILC2pwI4qYDSnkDHW2i3tCE1IYI3SnQEObvIXp7qHrz7NmOIcjJB4zgqi-l_EqotqQUXok7o6xOqk9PBYy8PPhnljxKIXGKQe_l3DHKJQQLIFEMSP1v7zO2E3W_pve8JeLECKmg19l5ZbcIfroGm4Uwk7u2Jw-TKd4Neru0641FH2Tnzf_O8-aeMHo01qfNXPGLYu9nb5LsEGagk8tOyOMveACNky4Gyn3DKxLU</recordid><startdate>20140131</startdate><enddate>20140131</enddate><creator>Olsen, J</creator><creator>Peroski, M</creator><creator>Kiczek, M</creator><creator>Grignol, G</creator><creator>Merchenthaler, I</creator><creator>Dudas, B</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0190-9975</orcidid></search><sort><creationdate>20140131</creationdate><title>Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus</title><author>Olsen, J ; Peroski, M ; Kiczek, M ; Grignol, G ; Merchenthaler, I ; Dudas, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-6b555eefee1d78642d86f58e71e13bf261504122f01d5b1b9280700658a6d0e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Axons - metabolism</topic><topic>beta-Endorphin - metabolism</topic><topic>Biological and medical sciences</topic><topic>dynorphin</topic><topic>Dynorphins - metabolism</topic><topic>endorphin</topic><topic>enkephalin</topic><topic>Enkephalin, Leucine - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GHRH</topic><topic>growth</topic><topic>Growth Hormone-Releasing Hormone - metabolism</topic><topic>Humans</topic><topic>hypothalamus</topic><topic>Hypothalamus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Median Eminence - metabolism</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Opioid Peptides - metabolism</topic><topic>Pituitary Gland, Posterior - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olsen, J</creatorcontrib><creatorcontrib>Peroski, M</creatorcontrib><creatorcontrib>Kiczek, M</creatorcontrib><creatorcontrib>Grignol, G</creatorcontrib><creatorcontrib>Merchenthaler, I</creatorcontrib><creatorcontrib>Dudas, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olsen, J</au><au>Peroski, M</au><au>Kiczek, M</au><au>Grignol, G</au><au>Merchenthaler, I</au><au>Dudas, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2014-01-31</date><risdate>2014</risdate><volume>258</volume><spage>238</spage><epage>245</epage><pages>238-245</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Highlights • The majority of the GHRH perikarya form juxtapositions with enkephalinergic fibers. • Endorphinergic-GHRH associations are much less frequent. • Dynorphinergic-GHRH juxtapositions are extremely rare in the human hypothalamus. • Thus endorphins/dynorphins play a minor role in the regulation of growth via GHRH. • Enkephalinergic-GHRH contacts may represent the impact of opiates on growth.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>24239719</pmid><doi>10.1016/j.neuroscience.2013.11.011</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0190-9975</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2014-01, Vol.258, p.238-245 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1490765667 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Axons - metabolism beta-Endorphin - metabolism Biological and medical sciences dynorphin Dynorphins - metabolism endorphin enkephalin Enkephalin, Leucine - metabolism Female Fundamental and applied biological sciences. Psychology GHRH growth Growth Hormone-Releasing Hormone - metabolism Humans hypothalamus Hypothalamus - metabolism Immunohistochemistry Male Median Eminence - metabolism Neurology Neurons - metabolism Opioid Peptides - metabolism Pituitary Gland, Posterior - metabolism Vertebrates: nervous system and sense organs |
| title | Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T06%3A15%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intimate%20associations%20between%20the%20endogenous%20opiate%20systems%20and%20the%20growth%20hormone-releasing%20hormone%20system%20in%20the%20human%20hypothalamus&rft.jtitle=Neuroscience&rft.au=Olsen,%20J&rft.date=2014-01-31&rft.volume=258&rft.spage=238&rft.epage=245&rft.pages=238-245&rft.issn=0306-4522&rft.eissn=1873-7544&rft.coden=NRSCDN&rft_id=info:doi/10.1016/j.neuroscience.2013.11.011&rft_dat=%3Cproquest_cross%3E1490765667%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1490765667&rft_id=info:pmid/24239719&rft_els_id=1_s2_0_S0306452213009512&rfr_iscdi=true |