Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus

Highlights • The majority of the GHRH perikarya form juxtapositions with enkephalinergic fibers. • Endorphinergic-GHRH associations are much less frequent. • Dynorphinergic-GHRH juxtapositions are extremely rare in the human hypothalamus. • Thus endorphins/dynorphins play a minor role in the regulat...

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Veröffentlicht in:	Neuroscience 2014-01, Vol.258, p.238-245
Hauptverfasser:	Olsen, J, Peroski, M, Kiczek, M, Grignol, G, Merchenthaler, I, Dudas, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Axons - metabolism beta-Endorphin - metabolism Biological and medical sciences dynorphin Dynorphins - metabolism endorphin enkephalin Enkephalin, Leucine - metabolism Female Fundamental and applied biological sciences. Psychology GHRH growth Growth Hormone-Releasing Hormone - metabolism Humans hypothalamus Hypothalamus - metabolism Immunohistochemistry Male Median Eminence - metabolism Neurology Neurons - metabolism Opioid Peptides - metabolism Pituitary Gland, Posterior - metabolism Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • The majority of the GHRH perikarya form juxtapositions with enkephalinergic fibers. • Endorphinergic-GHRH associations are much less frequent. • Dynorphinergic-GHRH juxtapositions are extremely rare in the human hypothalamus. • Thus endorphins/dynorphins play a minor role in the regulation of growth via GHRH. • Enkephalinergic-GHRH contacts may represent the impact of opiates on growth.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.11.011