Guidelines for optimizing design and analysis of clinical studies of nutrient effects

Presented here is a system to standardize clinical studies of nutrient effects, using nutrient‐specific physiological criteria. These guidelines are based mainly on analysis of the typical sigmoid curve of biological response to nutrients and are intended for design, interpretation, and pooling of s...

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Veröffentlicht in:	Nutrition reviews 2014-01, Vol.72 (1), p.48-54
1. Verfasser:	Heaney, Robert P
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical Protocols - standards clinical studies Clinical trials Design optimization Evidence-Based Medicine Guidelines as Topic Humans Meta-analysis nutrient effects Nutrition Physiology Research Design Review Literature as Topic sigmoid curve study design Systematic review
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Beschreibung
Zusammenfassung:	Presented here is a system to standardize clinical studies of nutrient effects, using nutrient‐specific physiological criteria. These guidelines are based mainly on analysis of the typical sigmoid curve of biological response to nutrients and are intended for design, interpretation, and pooling of studies of nutrient effects. Five rules have been articulated for individual studies of nutrients, and six for systematic reviews and/or meta‐analyses.
ISSN:	0029-6643 1753-4887
DOI:	10.1111/nure.12090