Modern Chemotherapy Mitigates Adverse Prognostic Effect of Regional Nodal Metastases in Stage IV Colorectal Cancer

Background In colorectal cancer, the involvement of regional lymph nodes with metastasis is an established prognostic factor. The impact of the number of positive nodes on patient outcome with stage IV disease is not well defined. Methods A retrospective review was performed of 1,421 patients at two...

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Veröffentlicht in:	Journal of gastrointestinal surgery 2014, Vol.18 (1), p.69-74
Hauptverfasser:	Thomay, Alan A., Nagorney, David M., Cohen, Steven J., Sigurdson, Elin R., Truty, Mark J., Burtness, Barbara, Hall, Michael J., Chun, Yun Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	2013 SSAT Plenary Presentation Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Camptothecin - administration & dosage Camptothecin - analogs & derivatives Cancer therapies Chemotherapy Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Gastroenterology Hepatectomy Humans Irinotecan Kaplan-Meier Estimate Liver Liver Neoplasms - drug therapy Liver Neoplasms - secondary Liver Neoplasms - surgery Lung Neoplasms - drug therapy Lung Neoplasms - secondary Lung Neoplasms - surgery Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Lymphatic system Male Medical prognosis Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Staging Oncology Organoplatinum Compounds - administration & dosage Ovarian Neoplasms - drug therapy Ovarian Neoplasms - secondary Ovarian Neoplasms - surgery Oxaliplatin Patients Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Peritoneal Neoplasms - surgery Prognosis Retrospective Studies Statistical analysis Surgery Tumors Young Adult
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Zusammenfassung:	Background In colorectal cancer, the involvement of regional lymph nodes with metastasis is an established prognostic factor. The impact of the number of positive nodes on patient outcome with stage IV disease is not well defined. Methods A retrospective review was performed of 1,421 patients at two tertiary referral centers with stage IV colorectal cancer who underwent primary tumor resection. Associations between regional nodes, lymph node ratio (LNR), and overall survival (OS) from date of diagnosis were analyzed. Results The number of positive regional nodes and LNR correlated with multiple sites of metastases ( p
ISSN:	1091-255X 1873-4626
DOI:	10.1007/s11605-013-2329-8