Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children
Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcyRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcyRI...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2014-01, Vol.209 (2), p.285-289 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 289 |
|---|---|
| container_issue | 2 |
| container_start_page | 285 |
| container_title | The Journal of infectious diseases |
| container_volume | 209 |
| creator | Adu, Bright Jepsen, Micha Phill Grønholm Gerds, Thomas A. Kyei-Baafour, Eric Christiansen, Michael Dodoo, Daniel Theisen, Michael |
| description | Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcyRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcyRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies. |
| doi_str_mv | 10.1093/infdis/jit422 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490752715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>43707959</jstor_id><sourcerecordid>43707959</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-b491b59fac22ef2161606c597977b21c5863833c9347fc36fe08f91380cf31a73</originalsourceid><addsrcrecordid>eNo90UFr2zAUB3AxNtYs3XHHDV0G3cGtpGdJ1mWQmiYdtLR029nIikQUbMuVnEG_xT7yNJzmpAf6_d_h_RH6RMklJQqu_OC2Pl3t_VQy9gYtKAdZCEHhLVoQwlhBK6XO0IeU9oSQEoR8j84YKOCMkAX6uzZ4o_te4ydr7DiFiOEaX6zrzRNcF-aSAdTfV0VMnACRUH3Dj6F76UMcdz71-D5svfM24Wln8WMMkzWT_2PxjXN5wsHhe93p6DX-OVqTqcGrYfJtjuWQH_Bmpwft9YDrne-20Q7n6J3TXbIfj-8S_V7f_Kpvi7uHzY96dVeYkpOpaEtFW66cNoxZx6igggjDlVRStowaXgmoAIyCUjoDwllSOUWhIsYB1RKW6GLeO8bwfLBpanqfjO06PdhwSA0tFZGcyXzPJSpmamJIKVrXjNH3Or40lDT_S2jmEpq5hOy_HFcf2t5uT_r16hl8PQKdjO5c1IPJ8ZOrgCpR0ew-z26fcjGn_xIkkYor-AcD_pfb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490752715</pqid></control><display><type>article</type><title>Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children</title><source>MEDLINE</source><source>Oxford Journals Online</source><source>Alma/SFX Local Collection</source><source>JSTOR</source><creator>Adu, Bright ; Jepsen, Micha Phill Grønholm ; Gerds, Thomas A. ; Kyei-Baafour, Eric ; Christiansen, Michael ; Dodoo, Daniel ; Theisen, Michael</creator><creatorcontrib>Adu, Bright ; Jepsen, Micha Phill Grønholm ; Gerds, Thomas A. ; Kyei-Baafour, Eric ; Christiansen, Michael ; Dodoo, Daniel ; Theisen, Michael</creatorcontrib><description>Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcyRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcyRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jit422</identifier><identifier>PMID: 23935200</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antibodies ; Antibodies, Protozoan - immunology ; Antigens ; Biological and medical sciences ; Child ; Child, Preschool ; Cohort Studies ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Genotypes ; Ghana ; GPI-Linked Proteins - genetics ; Human protozoal diseases ; Humans ; Infant ; Infectious diseases ; Logistic regression ; Malaria ; Malaria - immunology ; Malaria vaccines ; Male ; Medical sciences ; Microbiology ; Neutrophils ; Parasitemia ; PARASITES ; Parasitic diseases ; Polymorphism, Single Nucleotide ; Protective effects ; Protozoal diseases ; Receptors, IgG - genetics ; Sickle cell trait</subject><ispartof>The Journal of infectious diseases, 2014-01, Vol.209 (2), p.285-289</ispartof><rights>Copyright © 2014 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-b491b59fac22ef2161606c597977b21c5863833c9347fc36fe08f91380cf31a73</citedby><cites>FETCH-LOGICAL-c450t-b491b59fac22ef2161606c597977b21c5863833c9347fc36fe08f91380cf31a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43707959$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/43707959$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28319681$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23935200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adu, Bright</creatorcontrib><creatorcontrib>Jepsen, Micha Phill Grønholm</creatorcontrib><creatorcontrib>Gerds, Thomas A.</creatorcontrib><creatorcontrib>Kyei-Baafour, Eric</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><creatorcontrib>Dodoo, Daniel</creatorcontrib><creatorcontrib>Theisen, Michael</creatorcontrib><title>Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcyRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcyRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.</description><subject>Antibodies</subject><subject>Antibodies, Protozoan - immunology</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotypes</subject><subject>Ghana</subject><subject>GPI-Linked Proteins - genetics</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Logistic regression</subject><subject>Malaria</subject><subject>Malaria - immunology</subject><subject>Malaria vaccines</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Neutrophils</subject><subject>Parasitemia</subject><subject>PARASITES</subject><subject>Parasitic diseases</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Protective effects</subject><subject>Protozoal diseases</subject><subject>Receptors, IgG - genetics</subject><subject>Sickle cell trait</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90UFr2zAUB3AxNtYs3XHHDV0G3cGtpGdJ1mWQmiYdtLR029nIikQUbMuVnEG_xT7yNJzmpAf6_d_h_RH6RMklJQqu_OC2Pl3t_VQy9gYtKAdZCEHhLVoQwlhBK6XO0IeU9oSQEoR8j84YKOCMkAX6uzZ4o_te4ydr7DiFiOEaX6zrzRNcF-aSAdTfV0VMnACRUH3Dj6F76UMcdz71-D5svfM24Wln8WMMkzWT_2PxjXN5wsHhe93p6DX-OVqTqcGrYfJtjuWQH_Bmpwft9YDrne-20Q7n6J3TXbIfj-8S_V7f_Kpvi7uHzY96dVeYkpOpaEtFW66cNoxZx6igggjDlVRStowaXgmoAIyCUjoDwllSOUWhIsYB1RKW6GLeO8bwfLBpanqfjO06PdhwSA0tFZGcyXzPJSpmamJIKVrXjNH3Or40lDT_S2jmEpq5hOy_HFcf2t5uT_r16hl8PQKdjO5c1IPJ8ZOrgCpR0ew-z26fcjGn_xIkkYor-AcD_pfb</recordid><startdate>20140115</startdate><enddate>20140115</enddate><creator>Adu, Bright</creator><creator>Jepsen, Micha Phill Grønholm</creator><creator>Gerds, Thomas A.</creator><creator>Kyei-Baafour, Eric</creator><creator>Christiansen, Michael</creator><creator>Dodoo, Daniel</creator><creator>Theisen, Michael</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140115</creationdate><title>Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children</title><author>Adu, Bright ; Jepsen, Micha Phill Grønholm ; Gerds, Thomas A. ; Kyei-Baafour, Eric ; Christiansen, Michael ; Dodoo, Daniel ; Theisen, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-b491b59fac22ef2161606c597977b21c5863833c9347fc36fe08f91380cf31a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antibodies</topic><topic>Antibodies, Protozoan - immunology</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotypes</topic><topic>Ghana</topic><topic>GPI-Linked Proteins - genetics</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Logistic regression</topic><topic>Malaria</topic><topic>Malaria - immunology</topic><topic>Malaria vaccines</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Neutrophils</topic><topic>Parasitemia</topic><topic>PARASITES</topic><topic>Parasitic diseases</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Protective effects</topic><topic>Protozoal diseases</topic><topic>Receptors, IgG - genetics</topic><topic>Sickle cell trait</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adu, Bright</creatorcontrib><creatorcontrib>Jepsen, Micha Phill Grønholm</creatorcontrib><creatorcontrib>Gerds, Thomas A.</creatorcontrib><creatorcontrib>Kyei-Baafour, Eric</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><creatorcontrib>Dodoo, Daniel</creatorcontrib><creatorcontrib>Theisen, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adu, Bright</au><au>Jepsen, Micha Phill Grønholm</au><au>Gerds, Thomas A.</au><au>Kyei-Baafour, Eric</au><au>Christiansen, Michael</au><au>Dodoo, Daniel</au><au>Theisen, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2014-01-15</date><risdate>2014</risdate><volume>209</volume><issue>2</issue><spage>285</spage><epage>289</epage><pages>285-289</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcyRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcyRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>23935200</pmid><doi>10.1093/infdis/jit422</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2014-01, Vol.209 (2), p.285-289 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1490752715 |
| source | MEDLINE; Oxford Journals Online; Alma/SFX Local Collection; JSTOR |
| subjects | Antibodies Antibodies, Protozoan - immunology Antigens Biological and medical sciences Child Child, Preschool Cohort Studies Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genotypes Ghana GPI-Linked Proteins - genetics Human protozoal diseases Humans Infant Infectious diseases Logistic regression Malaria Malaria - immunology Malaria vaccines Male Medical sciences Microbiology Neutrophils Parasitemia PARASITES Parasitic diseases Polymorphism, Single Nucleotide Protective effects Protozoal diseases Receptors, IgG - genetics Sickle cell trait |
| title | Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T18%3A52%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fc%20Gamma%20Receptor%203B%20(FCGR3B-c.233C%3EA-rs5030738)%20Polymorphism%20Modifies%20the%20Protective%20Effect%20of%20Malaria%20Specific%20Antibodies%20in%20Ghanaian%20Children&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Adu,%20Bright&rft.date=2014-01-15&rft.volume=209&rft.issue=2&rft.spage=285&rft.epage=289&rft.pages=285-289&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1093/infdis/jit422&rft_dat=%3Cjstor_proqu%3E43707959%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1490752715&rft_id=info:pmid/23935200&rft_jstor_id=43707959&rfr_iscdi=true |