Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children

Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcyRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcyRI...

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Veröffentlicht in:	The Journal of infectious diseases 2014-01, Vol.209 (2), p.285-289
Hauptverfasser:	Adu, Bright, Jepsen, Micha Phill Grønholm, Gerds, Thomas A., Kyei-Baafour, Eric, Christiansen, Michael, Dodoo, Daniel, Theisen, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Protozoan - immunology Antigens Biological and medical sciences Child Child, Preschool Cohort Studies Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genotypes Ghana GPI-Linked Proteins - genetics Human protozoal diseases Humans Infant Infectious diseases Logistic regression Malaria Malaria - immunology Malaria vaccines Male Medical sciences Microbiology Neutrophils Parasitemia PARASITES Parasitic diseases Polymorphism, Single Nucleotide Protective effects Protozoal diseases Receptors, IgG - genetics Sickle cell trait
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Zusammenfassung:	Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcyRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcyRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jit422