A novel highly reactive Fab antibody for breast cancer tissue diagnostics and staging also discriminates a subset of good prognostic triple-negative breast cancers

Highlights • FabC4 identifies a subset of good prognostic TNBC patients. • FabC4 positivity is associated with disease free survival of 74 months in TNBCs. • FabC4 is associated with higher histological grades. • FabC4 presents an overall sensitivity of BC detection of 70%. • FabC4 targets a conform...

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Veröffentlicht in:	Cancer letters 2014-02, Vol.343 (2), p.275-285
Hauptverfasser:	Araújo, Thaise G, Paiva, Carlos E, Rocha, Rafael M, Maia, Yara C.P, Sena, Angela A.S, Ueira-Vieira, Carlos, Carneiro, Ana Paula, Almeida, Juliana F, de Faria, Paulo R, Santos, Donizeti W, Calábria, Luanda, Alcântara, Tânia M, Soares, Fernando A, Goulart, Luiz R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Amino Acid Sequence Antigens Breast cancer Breast Neoplasms - diagnosis Cancer therapies Combinatorial library Disease-Free Survival Female Hematology, Oncology and Palliative Medicine Humans Immunoglobulin Fab Fragments - genetics Ligands Mass Spectrometry Metastasis Microarray Analysis Middle Aged Neoplasm Staging Peptide Library Phage display Prognosis Recombinant antibody Triple Negative Breast Neoplasms - diagnosis
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Zusammenfassung:	Highlights • FabC4 identifies a subset of good prognostic TNBC patients. • FabC4 positivity is associated with disease free survival of 74 months in TNBCs. • FabC4 is associated with higher histological grades. • FabC4 presents an overall sensitivity of BC detection of 70%. • FabC4 targets a conformational Cytokeratin-10 epitope.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.09.029