Social isolation stress reduces hippocampal long-term potentiation: Effect of animal strain and involvement of glucocorticoid receptors

Highlights • Long-term potentiation was measured in hippocampal slices from two mouse strains. • The level of long-term potentiation is different in one strain than the other. • Social isolation stress reduces long-term potentiation expression in both strains. • Corticosterone levels increase after...

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Veröffentlicht in:	Neuroscience 2014-01, Vol.256, p.262-270
Hauptverfasser:	Kamal, A, Ramakers, G.M.J, Altinbilek, B, Kas, M.J.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Biophysics Corticosterone - pharmacology Drug Administration Routes Electric Stimulation Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - physiopathology Hormone Antagonists - pharmacology In Vitro Techniques Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Mice Mice, Inbred Strains Mifepristone - pharmacology Neurology Receptors, Glucocorticoid - metabolism Social Isolation Stress, Psychological - pathology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Long-term potentiation was measured in hippocampal slices from two mouse strains. • The level of long-term potentiation is different in one strain than the other. • Social isolation stress reduces long-term potentiation expression in both strains. • Corticosterone levels increase after social stress isolation. • Long-term potentiation was restored by glucocorticoid receptor antagonist.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.10.016