Effects of voluntary exercise on hippocampal long-term potentiation in morphine-dependent rats

Highlights • Chronic exposure to opiates alters synaptic plasticity and cognitive functions. • Exercise enhances hippocampal LTP and cognitive functions. • Chronic morphine increases population spike LTP in the dentate gyrus of the hippocampus. • Exercise enhances hippocampal population spike LTP in...

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Veröffentlicht in:	Neuroscience 2014-01, Vol.256, p.83-90
Hauptverfasser:	Miladi-Gorji, H, Rashidy-Pour, A, Fathollahi, Y, Semnanian, S, Jadidi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analysis of Variance Animals Biological and medical sciences Disease Models, Animal Electric Stimulation Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Hippocampus - physiopathology Long-Term Potentiation - physiology Male Medical sciences Morphine Dependence - pathology Morphine Dependence - rehabilitation Neurology Neuropharmacology Pharmacology. Drug treatments Physical Conditioning, Animal Rats Rats, Wistar Time Factors Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Chronic exposure to opiates alters synaptic plasticity and cognitive functions. • Exercise enhances hippocampal LTP and cognitive functions. • Chronic morphine increases population spike LTP in the dentate gyrus of the hippocampus. • Exercise enhances hippocampal population spike LTP in morphine-dependent rats. • These results suggest an additive effect between exercise and morphine on LTP.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.056