Detection of the ovarian cancer biomarker CA-125 using chemiluminescence resonance energy transfer to graphene quantum dots

An immunoassay has been developed for the detection of the ovarian cancer biomarker CA-125 by utilizing the chemiluminescence resonance energy transfer to graphene quantum dots. This biosensor shows a wide linear range from 0.1 U mL(-1) to 600 U mL(-1) with a limit of detection of 0.05 U mL(-1) for...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (11), p.1344-1346
Hauptverfasser:	Al-Ogaidi, Israa, Gou, Honglei, Aguilar, Zoraida P, Guo, Shouwu, Melconian, Alice K, Al-Kazaz, Abdul Kareem A, Meng, Fanke, Wu, Nianqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Antibodies - immunology Biosensing Techniques CA-125 Antigen - analysis CA-125 Antigen - immunology Energy Transfer Female Graphite - chemistry Horseradish Peroxidase - chemistry Humans Hydrogen Peroxide - chemistry Immunoassay - methods Luminescence Luminescent Measurements Ovarian Neoplasms Quantum Dots - chemistry
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Beschreibung
Zusammenfassung:	An immunoassay has been developed for the detection of the ovarian cancer biomarker CA-125 by utilizing the chemiluminescence resonance energy transfer to graphene quantum dots. This biosensor shows a wide linear range from 0.1 U mL(-1) to 600 U mL(-1) with a limit of detection of 0.05 U mL(-1) for CA-125 in a buffer solution.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc47701k