Markers of epithelial-mesenchymal transition in renal cell carcinoma

To study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3-6 months) and a long-ter...

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Veröffentlicht in:	Experimental oncology 2013-12, Vol.35 (4), p.325-327
Hauptverfasser:	Dumanskiy, Y V, Kudriashov, A G, Vasilenko, I V, Kondratyuk, R B, Gulkov, Y K, Cyrillichystiakov, R S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - therapy Epithelial-Mesenchymal Transition Humans Immunohistochemistry Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Neoplasm Grading
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Zusammenfassung:	To study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3-6 months) and a long-term survival group (17-24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96.4% in a short-term survival group and 42.1% in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3-4 occurred in 100% of cases in a short-term survival group versus 68.4% in a long-term survival group. The rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia.
ISSN:	1812-9269