High Ki-67 score is indicative of a greater benefit from adjuvant chemotherapy when added to endocrine therapy in Luminal B HER2 negative and node-positive breast cancer

Abstract Background The indication of adjuvant chemotherapy for patients with highly proliferative estrogen receptor-positive breast cancer is controversial. We analyzed the predictive value of Ki67 for the efficacy of adjuvant chemotherapy in patients with estrogen receptor-positive, node-positive...

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Veröffentlicht in:	Breast (Edinburgh) 2014-02, Vol.23 (1), p.69-75
Hauptverfasser:	Criscitiello, Carmen, Disalvatore, Davide, De Laurentiis, Michele, Gelao, Lucia, Fumagalli, Luca, Locatelli, Marzia, Bagnardi, Vincenzo, Rotmensz, Nicole, Esposito, Angela, Minchella, Ida, De Placido, Sabino, Santangelo, Michele, Viale, Giuseppe, Goldhirsch, Aron, Curigliano, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Hormonal - therapeutic use Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Lobular - drug therapy Carcinoma, Lobular - metabolism Carcinoma, Lobular - pathology Chemotherapy Chemotherapy, Adjuvant Cohort Studies Female Hematology, Oncology and Palliative Medicine Hormonotherapy Humans Ki-67 Antigen - metabolism Ki67 Logistic Models Luminal B Lymphatic Metastasis Middle Aged Multivariate Analysis Nodal involvement Prognosis Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Retrospective Studies
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