Increased CPA6 promoter methylation in focal epilepsy and in febrile seizures

Highlights • We assessed DNA methylation level of CPA6 promoter in peripheral blood of epileptic patients. • CPA6 higher methylation status was found in focal epilepsy patients and febrile seizures patients. • In epigenetic epilepsy field, first time such results have been found in blood samples of...

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Veröffentlicht in:	Epilepsy research 2014-01, Vol.108 (1), p.144-148
Hauptverfasser:	Belhedi, N, Perroud, N, Karege, F, Vessaz, M, Malafosse, A, Salzmann, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Base Sequence Biological and medical sciences Carboxypeptidases A - genetics Carboxypeptidases A - metabolism Cohort Studies CPA6 DNA methylation DNA Methylation - genetics Epilepsies, Partial - diagnosis Epilepsies, Partial - genetics Epilepsies, Partial - metabolism Febrile seizures Focal epilepsy Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Molecular Sequence Data Nervous system (semeiology, syndromes) Neurology Promoter Regions, Genetic - genetics Seizures, Febrile - diagnosis Seizures, Febrile - genetics Seizures, Febrile - metabolism Young Adult
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Zusammenfassung:	Highlights • We assessed DNA methylation level of CPA6 promoter in peripheral blood of epileptic patients. • CPA6 higher methylation status was found in focal epilepsy patients and febrile seizures patients. • In epigenetic epilepsy field, first time such results have been found in blood samples of epileptic patients.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2013.10.007