Vasculitis following implantation of a ventriculoperitoneal shunt tube made of silicone

Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests for both myeloperoxidase ANCA and proteinase 3 ANCA were initially weakly positive. Antinuclear and other autoantibodies were also present. We diagnosed ANCA-associated vasculitis, probably induced by the silicone tube.