Peripheral injections of cholecystokinin, apelin, ghrelin and orexin in cavefish ( Astyanax fasciatus mexicanus ): Effects on feeding and on the brain expression levels of tyrosine hydroxylase, mechanistic target of rapamycin and appetite-related hormones

Highlights • CCK injections decreased feeding and apelin brain expression. • Apelin injections increased feeding and TH, mTOR and orexin brain expressions. • Orexin (OX) treatment increased feeding and brain TH expression. • Ghrelin injections increased feeding and mTOR and orexin brain expressions....

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Veröffentlicht in:	General and comparative endocrinology 2014-01, Vol.196, p.34-40
Hauptverfasser:	Penney, Carla C, Volkoff, Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Appetite - physiology Blind cavefish Brain - drug effects Brain - enzymology Characidae Chemokines - administration & dosage Cholagogues and Choleretics - administration & dosage Cholecystokinin - administration & dosage Eating - drug effects Endocrinology & Metabolism Feeding Ghrelin - administration & dosage Hormone Hormones - pharmacology Immunosuppressive Agents - pharmacology Injection Intracellular Signaling Peptides and Proteins - administration & dosage mRNA expression Neuropeptides - administration & dosage Neurotransmitter Agents - administration & dosage Orexins Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Sirolimus - pharmacology Tyrosine 3-Monooxygenase - antagonists & inhibitors Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism
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Beschreibung
Zusammenfassung:	Highlights • CCK injections decreased feeding and apelin brain expression. • Apelin injections increased feeding and TH, mTOR and orexin brain expressions. • Orexin (OX) treatment increased feeding and brain TH expression. • Ghrelin injections increased feeding and mTOR and orexin brain expressions. • CCK, apelin, OX, ghrelin, TH and mTOR might regulate feeding in cavefish.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2013.11.015