Ruthenium-Catalyzed C–H Functionalization of Arylpyrazoles: Regioselective Acylation with Acid Chlorides

Ruthenium-Catalyzed C–H Functionalization of Arylpyrazoles: Regioselective Acylation with Acid Chlorides

A ruthenium-catalyzed C–H acylation of arylpyrazoles with a variety of acyl chlorides is described. The acylation reaction exhibits good regioselectivity and both aromatic and aliphatic acyl chlorides can be effectively coupled to the arylpyrazoles at the ortho-position.

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Veröffentlicht in:Organic letters 2013-11, Vol.15 (22), p.5862-5865
Hauptverfasser: Liu, Po Man, Frost, Christopher G
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Catalysis
Hydrochloric Acid - chemistry
Molecular Structure
Pyrazoles - chemistry
Ruthenium - chemistry
Stereoisomerism
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Zusammenfassung:A ruthenium-catalyzed C–H acylation of arylpyrazoles with a variety of acyl chlorides is described. The acylation reaction exhibits good regioselectivity and both aromatic and aliphatic acyl chlorides can be effectively coupled to the arylpyrazoles at the ortho-position.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol402936c