ALIX and the multivesicular endosome: ALIX in Wonderland

Highlights • ALIX in mammalian cells and Bro1 in yeast share common properties in cargo sorting and ILV formation. • ALIX may operate not only during ILV formation but also ‘behind the mirror’ during ILV back-fusion.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in cell biology 2014-01, Vol.24 (1), p.19-25
Hauptverfasser:	Bissig, Christin, Gruenberg, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals back-fusion Bro1 Calcium-Binding Proteins - physiology Cell Cycle Proteins - physiology Cell Membrane - metabolism Cell Membrane - ultrastructure EGF receptor Endosomal Sorting Complexes Required for Transport - physiology ESCRT-mediated sorting Humans intralumenal vesicle (ILV) Multivesicular Bodies - metabolism Pathology Protein Transport Saccharomyces cerevisiae Proteins - physiology signaling receptor Transport Vesicles - metabolism Ubiquitinated Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights • ALIX in mammalian cells and Bro1 in yeast share common properties in cargo sorting and ILV formation. • ALIX may operate not only during ILV formation but also ‘behind the mirror’ during ILV back-fusion.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2013.10.009