Carotid intima-media thickness in children with familial hypercholesterolemia

Familial hypercholesterolemia (FH) predisposes patients to premature cardiovascular disease, with the process of atherosclerosis initiated in early childhood. As part of an ongoing trial to assess the efficacy and safety of rosuvastatin in children with FH aged 6 to 17 years, we report the differenc...

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Veröffentlicht in:	Circulation research 2014-01, Vol.114 (2), p.307-310
Hauptverfasser:	Kusters, Dorothé M, Wiegman, A, Kastelein, John J P, Hutten, Barbara A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors Biomarkers - blood Canada Carotid Arteries - diagnostic imaging Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - etiology Carotid Intima-Media Thickness Child Cholesterol, LDL - blood Europe Female Fluorobenzenes - therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - complications Hyperlipoproteinemia Type II - diagnosis Hyperlipoproteinemia Type II - drug therapy Hyperlipoproteinemia Type II - genetics Linear Models Logistic Models Male Multivariate Analysis Predictive Value of Tests Pyrimidines - therapeutic use Risk Factors Rosuvastatin Calcium Sex Factors Sulfonamides - therapeutic use United States
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Zusammenfassung:	Familial hypercholesterolemia (FH) predisposes patients to premature cardiovascular disease, with the process of atherosclerosis initiated in early childhood. As part of an ongoing trial to assess the efficacy and safety of rosuvastatin in children with FH aged 6 to 17 years, we report the differences in carotid intima-media thickness (cIMT) at baseline between children with FH and their unaffected siblings. B-mode ultrasound measurements of the carotid artery were made in 196 children with FH and 64 of their siblings. Mean (±SE) cIMT in children with FH was significantly greater than that of unaffected siblings (0.398±0.052 versus 0.377±0.045 mm; P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/CIRCRESAHA.114.301430