Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma
Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquanti...
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| Veröffentlicht in: | Experimental dermatology 2013-11, Vol.22 (11), p.757-759 |
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| container_title | Experimental dermatology |
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| creator | Hassel, Jessica C. Amann, Philipp M. Schadendorf, Dirk Eichmüller, Stefan B. Nagler, Markus Bazhin, Alexandr V. |
| description | Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P |
| doi_str_mv | 10.1111/exd.12236 |
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Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P < 0.001). In contrast, expression of LRAT was not significantly different (P = 0.339). High LRAT expression in melanoma metastases was inversely correlated with patient survival; Kaplan–Meier analysis revealed earlier melanoma‐related death (P = 0.003). Expression of LRAT might, therefore, be a prognostic marker of the clinical course of melanoma.</description><identifier>ISSN: 0906-6705</identifier><identifier>EISSN: 1600-0625</identifier><identifier>DOI: 10.1111/exd.12236</identifier><identifier>PMID: 24433184</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Acyltransferases - metabolism ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Cell Cycle ; Cell Proliferation ; cis-trans-Isomerases - metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; lecithin retinol acyltransferase ; Male ; Melanocytes - cytology ; melanoma ; Melanoma - diagnosis ; Melanoma - metabolism ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; prognostic marker ; RPE65 ; Skin Neoplasms - diagnosis ; Skin Neoplasms - metabolism ; Treatment Outcome ; vitamin A ; Vitamin A - chemistry</subject><ispartof>Experimental dermatology, 2013-11, Vol.22 (11), p.757-759</ispartof><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3986-ccc9d1e364c4efd6a8b05d8b7fdb11956026a83a0f4425c72946a1cd88186e273</citedby><cites>FETCH-LOGICAL-c3986-ccc9d1e364c4efd6a8b05d8b7fdb11956026a83a0f4425c72946a1cd88186e273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fexd.12236$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fexd.12236$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24433184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassel, Jessica C.</creatorcontrib><creatorcontrib>Amann, Philipp M.</creatorcontrib><creatorcontrib>Schadendorf, Dirk</creatorcontrib><creatorcontrib>Eichmüller, Stefan B.</creatorcontrib><creatorcontrib>Nagler, Markus</creatorcontrib><creatorcontrib>Bazhin, Alexandr V.</creatorcontrib><title>Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma</title><title>Experimental dermatology</title><addtitle>Exp Dermatol</addtitle><description>Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P < 0.001). In contrast, expression of LRAT was not significantly different (P = 0.339). High LRAT expression in melanoma metastases was inversely correlated with patient survival; Kaplan–Meier analysis revealed earlier melanoma‐related death (P = 0.003). Expression of LRAT might, therefore, be a prognostic marker of the clinical course of melanoma.</description><subject>Acyltransferases - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Cycle</subject><subject>Cell Proliferation</subject><subject>cis-trans-Isomerases - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>lecithin retinol acyltransferase</subject><subject>Male</subject><subject>Melanocytes - cytology</subject><subject>melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Prognosis</subject><subject>prognostic marker</subject><subject>RPE65</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - metabolism</subject><subject>Treatment Outcome</subject><subject>vitamin A</subject><subject>Vitamin A - chemistry</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PAyEQhonRaK0e_AOGox62wsKyu0etbTVpNBqNjRdC2dmK7kcFGu2_l9ram1wgk2fezDwgdEJJj4ZzAd9Fj8YxEzuoQwUhERFxsos6JCciEilJDtChc--E0JSlyT46iDlnjGa8gyZj0Ma_mQZb8KZpK6z0svJWNa4Eqxxg5bDC89ZD442q8Ny2s6Z13mhcK_sBFpetDc_KzBrVeFxDpZq2Vkdor1SVg-PN3UXPw8FT_yYa349u-5fjSLM8E5HWOi8oMME1h7IQKpuSpMimaVlMKc0TQeJQY4qUnMeJTuOcC0V1kWU0ExCnrIvO1rlhsM8FOC9r4zRUYQpoF05SnpOU0tXCXXS-RrVtnbNQyrk1YYmlpESuRMogUv6KDOzpJnYxraHYkn_mAnCxBr5MBcv_k-Rgcv0XGa07jPPwve0IEqVY_Yt8uRvJx0k6vHp5eJUT9gMdV40N</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Hassel, Jessica C.</creator><creator>Amann, Philipp M.</creator><creator>Schadendorf, Dirk</creator><creator>Eichmüller, Stefan B.</creator><creator>Nagler, Markus</creator><creator>Bazhin, Alexandr V.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma</title><author>Hassel, Jessica C. ; Amann, Philipp M. ; Schadendorf, Dirk ; Eichmüller, Stefan B. ; Nagler, Markus ; Bazhin, Alexandr V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3986-ccc9d1e364c4efd6a8b05d8b7fdb11956026a83a0f4425c72946a1cd88186e273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acyltransferases - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cell Cycle</topic><topic>Cell Proliferation</topic><topic>cis-trans-Isomerases - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>lecithin retinol acyltransferase</topic><topic>Male</topic><topic>Melanocytes - cytology</topic><topic>melanoma</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Prognosis</topic><topic>prognostic marker</topic><topic>RPE65</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - metabolism</topic><topic>Treatment Outcome</topic><topic>vitamin A</topic><topic>Vitamin A - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassel, Jessica C.</creatorcontrib><creatorcontrib>Amann, Philipp M.</creatorcontrib><creatorcontrib>Schadendorf, Dirk</creatorcontrib><creatorcontrib>Eichmüller, Stefan B.</creatorcontrib><creatorcontrib>Nagler, Markus</creatorcontrib><creatorcontrib>Bazhin, Alexandr V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassel, Jessica C.</au><au>Amann, Philipp M.</au><au>Schadendorf, Dirk</au><au>Eichmüller, Stefan B.</au><au>Nagler, Markus</au><au>Bazhin, Alexandr V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma</atitle><jtitle>Experimental dermatology</jtitle><addtitle>Exp Dermatol</addtitle><date>2013-11</date><risdate>2013</risdate><volume>22</volume><issue>11</issue><spage>757</spage><epage>759</epage><pages>757-759</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P < 0.001). In contrast, expression of LRAT was not significantly different (P = 0.339). High LRAT expression in melanoma metastases was inversely correlated with patient survival; Kaplan–Meier analysis revealed earlier melanoma‐related death (P = 0.003). Expression of LRAT might, therefore, be a prognostic marker of the clinical course of melanoma.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>24433184</pmid><doi>10.1111/exd.12236</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acyltransferases - metabolism Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Cell Cycle Cell Proliferation cis-trans-Isomerases - metabolism Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry lecithin retinol acyltransferase Male Melanocytes - cytology melanoma Melanoma - diagnosis Melanoma - metabolism Middle Aged Neoplasm Metastasis Prognosis prognostic marker RPE65 Skin Neoplasms - diagnosis Skin Neoplasms - metabolism Treatment Outcome vitamin A Vitamin A - chemistry |
| title | Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma |
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