Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma

Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquanti...

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Veröffentlicht in:	Experimental dermatology 2013-11, Vol.22 (11), p.757-759
Hauptverfasser:	Hassel, Jessica C., Amann, Philipp M., Schadendorf, Dirk, Eichmüller, Stefan B., Nagler, Markus, Bazhin, Alexandr V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - metabolism Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Cell Cycle Cell Proliferation cis-trans-Isomerases - metabolism Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry lecithin retinol acyltransferase Male Melanocytes - cytology melanoma Melanoma - diagnosis Melanoma - metabolism Middle Aged Neoplasm Metastasis Prognosis prognostic marker RPE65 Skin Neoplasms - diagnosis Skin Neoplasms - metabolism Treatment Outcome vitamin A Vitamin A - chemistry
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Zusammenfassung:	Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P
ISSN:	0906-6705 1600-0625
DOI:	10.1111/exd.12236