Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji–Trost Reaction: Enantioselective Synthesis of Allokainates

Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji–Trost Reaction: Enantioselective Synthesis of Allokainates

Organocatalyzed Tsuji–Trost cyclization of 3b proceeds with asymmetric induction and allows for stereoselective synthesis of (+)-allokainic acid. The stereochemical outcome of the cyclization was predicted by calculations.

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Veröffentlicht in:Organic letters 2014-01, Vol.16 (1), p.34-37
Hauptverfasser: Vulovic, Bojan, Gruden-Pavlovic, Maja, Matovic, Radomir, Saicic, Radomir N
Format: Artikel
Sprache:eng
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Zusammenfassung:Organocatalyzed Tsuji–Trost cyclization of 3b proceeds with asymmetric induction and allows for stereoselective synthesis of (+)-allokainic acid. The stereochemical outcome of the cyclization was predicted by calculations.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol4028557