Techniques and results of lobar lung transplantations

OBJECTIVES We report our experience of lobar lung transplantations (LLTs) in patients with small thoracic volume. METHODS Since 1988, 50 LLTs were done for cystic fibrosis (n = 35), fibrosis (n = 7), bronchiectasis (n = 3), emphysema (n = 3) and lymphangiomyomatosis (n = 2). There were 44 females and 6 males (mean age 31 ± 13 years, mean size 155 ± 5.5 cm and mean predicted total lung capacity (TLC) 4463 ± 598 ml). Mean ratio between donor and recipient-predicted TLC was 1.65 ± 0.26. Six patients were listed in high emergency, 2 of them on ECMO as a bridge to transplantation. Forty middle/lower right lobe with left lower LLT, four bilateral lower LLT and six split left lung LLT were performed through a clamshell incision (n = 12) or a bilateral antero-lateral thoracotomy (n = 38), with epidural analgesia in 17 cases. Thirty-two patients were transplanted under circulatory support (CPB n = 16, veno-arterial ECMO n = 16). In 11 cases, the right venous anastomosis was enlarged by a pericardial cuff. Ischaemic time was 4.4 ± 1.2 h for the first lobe and 6.1 ± 1.3 h for the second. RESULTS Median mechanical ventilation weaning time was 10.5 (1-136) days. Four patients were extubated in the operating room. Ten patients needed ECMO for primary graft dysfunction. In-hospital mortality was 28% related to sepsis (n = 6), PGD (n = 3), haemorrhage (n = 2), broncho-vascular fistula (n = 1), and multiorgan failure (n = 2). Eight patients required endoscopic treatments for airway complications. Mean best FEV1 was 72 ± 16% of the theoretical value. The actuarial 3-year and 5-year survival rates were 60 and 46%, respectively. CONCLUSIONS LLTs are a reliable solution and can be performed with satisfactory functional results and survival rates.