Participation of superoxide in luminol-dependent chemiluminescence triggered by mineral dust in rabbit alveolar macrophages

Participation of superoxide in luminol-dependent chemiluminescence triggered by mineral dust in rabbit alveolar macrophages

Luminol-dependent chemiluminescence (CL) triggered by mineral dust in rabbit alveolar macrophages depended on superoxide production as revealed by inhibition by superoxide dismutase and ferricytochrome c. The contribution of superoxide changed in the course of CL peak between 80–20%. The effects of...

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Veröffentlicht in:Immunology letters 1987-08, Vol.15 (4), p.329-334
Hauptverfasser: Wilhelm, J., Vilím, V., Brzák, P.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chemiluminescence
Cytochrome c Group - pharmacology
Deferoxamine - pharmacology
Desferal
Dust
Ferricytochrome c
Luminescent Measurements
Luminol - pharmacology
Macrophages - metabolism
Pulmonary Alveoli - cytology
Pyridazines - pharmacology
Quartz - toxicity
Rabbits
Silicon Dioxide - toxicity
Superoxide
Superoxides - metabolism
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Zusammenfassung:Luminol-dependent chemiluminescence (CL) triggered by mineral dust in rabbit alveolar macrophages depended on superoxide production as revealed by inhibition by superoxide dismutase and ferricytochrome c. The contribution of superoxide changed in the course of CL peak between 80–20%. The effects of ferricytochrome c were concentration-dependent: both stimulation and inhibition were observed. Ferricytochrome c and desferal also inhibited CL pathway which was not superoxide-dependent.
ISSN:0165-2478
1879-0542
DOI:10.1016/0165-2478(87)90137-4