Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

Expression of an activated human c-H-ras oncogene under control of rat elastase I regulating elements leads to neoplasia of the fetal exocrine pancreas. Expression of the normal c-H-ras proto-oncogene in acinar cells leads to more subtle anomalies, but no tumors develop.

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Veröffentlicht in:Cell 1987-01, Vol.46 (6), p.1023-1034
Hauptverfasser: Quaife, C J, Pinkert, CA, Ornitz, D M, Palmiter, R D, Brinster, R L
Format: Artikel
Sprache:eng
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Zusammenfassung:Expression of an activated human c-H-ras oncogene under control of rat elastase I regulating elements leads to neoplasia of the fetal exocrine pancreas. Expression of the normal c-H-ras proto-oncogene in acinar cells leads to more subtle anomalies, but no tumors develop.
ISSN:0092-8674