Effects of stress and β-funaltrexamine pretreatment on morphine analgesia and opioid binding in rats

Effects of stress and β-funaltrexamine pretreatment on morphine analgesia and opioid binding in rats

This study was essentially an in vivo protection experiment designed to test further the hypothesis that stress induces release of endogenous opioids which then act at opioid receptors. Stress induces release of endogenous opioids that would protect opioid receptors from alkylation by beta -FNA. bet...

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Veröffentlicht in:Life sciences (1973) 1987-12, Vol.41 (26), p.2835-2844
Hauptverfasser: ADAMS, J. U, ANDREWS, J. S, HILLER, J. M, SIMON, E. J, HOLTZMAN, S. G
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics
Biological and medical sciences
brain
Medical sciences
Neuropharmacology
opiates
Pharmacology. Drug treatments
stress
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Zusammenfassung:This study was essentially an in vivo protection experiment designed to test further the hypothesis that stress induces release of endogenous opioids which then act at opioid receptors. Stress induces release of endogenous opioids that would protect opioid receptors from alkylation by beta -FNA. beta -FNA caused small and similar decreases in ( super(3)H)D-Ala super(2)NMePhe super(4)-Gly super(5)(ol)enkephalin (DAGO) binding in brain of both stressed and unstressed animals.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(87)90430-9