Comparative neurotoxicity and pyrrole-forming potential of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat

2,5-Hexanedione (2,5-HD), the neurotoxic metabolite of n-hexane, reacts with protein amines to form alkylpyrrole adducts. Pyrrolylation of neurofilament protein may be the initiating molecular event in 2,5-HD neuropathy. The present study compares the neurotoxic and pyrrole-forming potentials of 2,5...

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Veröffentlicht in:	Toxicol. Appl. Pharmacol.; (United States) 1988, Vol.92 (1), p.75-85
Hauptverfasser:	DeCaprio, Anthony P., Briggs, Robert G., Jackowski, Stephen J., Kim, James C.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	550501 - Metabolism- Tracer Techniques 560300 - Chemicals Metabolism & Toxicology ADDUCTS ALKANES ANIMALS Ataxia - chemically induced Axons - drug effects AZOLES BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOSYNTHESIS Body Weight - drug effects CENTRAL NERVOUS SYSTEM Chemical and industrial products toxicology. Toxic occupational diseases CHEMICAL REACTIONS COMPARATIVE EVALUATIONS CROSS-LINKING Cytoskeletal Proteins - analysis DEUTERIUM Deuterium - adverse effects ELECTROPHORESIS HETEROCYCLIC COMPOUNDS HEXANE Hexanones - toxicity HYDROCARBONS HYDROGEN ISOTOPES Injections, Intraperitoneal ISOTOPE APPLICATIONS ISOTOPE EFFECTS ISOTOPES KETONES Ketones - toxicity LIGHT NUCLEI Male MAMMALS Medical sciences NERVOUS SYSTEM NUCLEI ODD-ODD NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS PATHOLOGICAL CHANGES POLYMERIZATION PYRROLES Pyrroles - analysis Pyrroles - biosynthesis RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred Strains RODENTS Solvents SPINAL CORD Spinal Cord - drug effects STABLE ISOTOPES SYNTHESIS TOXICITY Toxicology TRACER TECHNIQUES VERTEBRATES
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