Study of the teratogenic potential of gum arabic

Gum arabic in the diet at 0, 1, 2, 4, 7.5 or 15% was available ad lib. to male and female Osborne-Mendel rats during premating and mating and throughout gestation. During gestation, the treated females consumed from 683 mg gum/kg body weight/day in the 1% group to 10,647 mg gum/kg/day in the 15% gro...

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Veröffentlicht in:	Food and chemical toxicology 1987-11, Vol.25 (11), p.815-821
Hauptverfasser:	Collins, T.F.X., Welsh, J.J., Black, T.N., Graham, S.L., Brown, L.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology acacia Animals Biological and medical sciences Body Weight - drug effects Bone and Bones - abnormalities diet Dose-Response Relationship, Drug Eating - drug effects Embryology: invertebrates and vertebrates. Teratology Female Fetus - drug effects Fundamental and applied biological sciences. Psychology gum arabic Gum Arabic - toxicity Male maternal nutrition Polysaccharides - toxicity Pregnancy Rats teratogenesis Teratology. Teratogens
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Beschreibung
Zusammenfassung:	Gum arabic in the diet at 0, 1, 2, 4, 7.5 or 15% was available ad lib. to male and female Osborne-Mendel rats during premating and mating and throughout gestation. During gestation, the treated females consumed from 683 mg gum/kg body weight/day in the 1% group to 10,647 mg gum/kg/day in the 15% group. The animals were killed on gestation day 20. There were no dose-related changes in maternal findings, number of foetuses, foetal viability or external, visceral or skeletal variations. No terata were seen.
ISSN:	0278-6915 1873-6351
DOI:	10.1016/0278-6915(87)90259-6