Alignment of BrDU-substituted chromatids in satellite association in human metaphase cells

The authors have studied the orientation of BrdU-substituted chromatids in satellite associations in cells double-stained to reveal both the Ag/As nucleolar organizer regions and, simultaneously, sister chromatid differentiation. In those satellite associations with all four chromatids joined by Ag stain, and with the axes in a virtually straight line, the authors have observed an excess of "concordant" configurations.