The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat

The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5–16 ug kg ) produced pronounced dose-dep...

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Veröffentlicht in:	Neuropharmacology 1987-08, Vol.26 (8), p.1243-1246
Hauptverfasser:	Verberne, A.J.M., Costa, M., Lewis, S.J., Louis, W.J., Beart, P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Biological and medical sciences Blood Pressure - drug effects Cardiovascular Physiological Phenomena Dibenzocycloheptenes - pharmacology Dizocilpine Maleate Heart Rate - drug effects Male Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Rats, Inbred WKY Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - metabolism Reflex - drug effects Sensory Receptor Cells - drug effects Serotonin - pharmacology Urethane
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Zusammenfassung:	The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5–16 ug kg ) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg kg i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc.
ISSN:	0028-3908 1873-7064
DOI:	10.1016/0028-3908(87)90277-2