Bromocriptine-Desipramine Protocol in Treatment of Cocaine Addiction

Thirty‐six male cocaine abusers, in withdrawal, were studied for 99 days in a double‐blind design. Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms. Adding desipramine to the bromocriptine regimen was significantly more effective than eith...

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Veröffentlicht in:	Journal of clinical pharmacology 1987-08, Vol.27 (8), p.549-554
Hauptverfasser:	Giannini, A. James, Billett, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Bromocriptine - administration & dosage Bromocriptine - therapeutic use Clinical Trials as Topic Cocaine Desipramine - administration & dosage Desipramine - therapeutic use Drug addictions Drug Therapy, Combination Humans Male Medical sciences Psychiatric Status Rating Scales Random Allocation Substance-Related Disorders - drug therapy Substance-Related Disorders - psychology Time Factors Toxicology
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Beschreibung
Zusammenfassung:	Thirty‐six male cocaine abusers, in withdrawal, were studied for 99 days in a double‐blind design. Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms. Adding desipramine to the bromocriptine regimen was significantly more effective than either placebo or bromocriptine alone. The authors hypothesize that these results support a model of dopamine depletion and receptor supersensitivity in cocaine withdrawal.
ISSN:	0091-2700 1552-4604
DOI:	10.1002/j.1552-4604.1987.tb03065.x