Dissociation of the cardiovascular and prolactin-releasing activities of norvaline super(2)-TRH

Dissociation of the cardiovascular and prolactin-releasing activities of norvaline super(2)-TRH

The effects of thyrotropin-releasing hormone (TRH) and norvaline super(2)-TRH (Nva super(2)-TRH) on blood pressure, heart rate and plasma prolactin levels in conscious rats have been compared. Two contrasting analogues are now available: 4-NO sub(2)-Im-TRH has full cardiovascular activity and no PRL...

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Veröffentlicht in:Neuropeptides (Edinburgh) 1987-01, Vol.10 (1), p.29-36
Hauptverfasser: Labroo, V M, Cohen, LA, Lozovsky, D, Siren, A-L, Feuerstein, G
Format: Artikel
Sprache:eng
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Zusammenfassung:The effects of thyrotropin-releasing hormone (TRH) and norvaline super(2)-TRH (Nva super(2)-TRH) on blood pressure, heart rate and plasma prolactin levels in conscious rats have been compared. Two contrasting analogues are now available: 4-NO sub(2)-Im-TRH has full cardiovascular activity and no PRL-releasing activity, while Nva super(2)-TRH has no cardiovascular activity and full PRL-releasing activity of TRH.
ISSN:0143-4179