A report on drug-induced kerato-conjunctivitis sicca in dogs

Kerato-conjunctivitis sicca is reported in beagle dogs treated with an antispasmodic compound for 26 weeks during a routine toxicity study. There was a deficiency of lachrymal secretion associated with keratitis and corneal vascularization. Histopathologically, the changes were characterized by vasc...

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Veröffentlicht in:	Journal of comparative pathology 1987-07, Vol.97 (4), p.385-391
Hauptverfasser:	Majeed, S.K., Gopinath, C., Heywood, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Conjunctiva - pathology Connective Tissue - pathology Cornea - pathology Dog Diseases - chemically induced Dog Diseases - pathology Dogs Epithelium - pathology Female Keratoconjunctivitis - veterinary Keratoconjunctivitis Sicca - chemically induced Keratoconjunctivitis Sicca - pathology Keratoconjunctivitis Sicca - veterinary Male Parasympatholytics - toxicity
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Zusammenfassung:	Kerato-conjunctivitis sicca is reported in beagle dogs treated with an antispasmodic compound for 26 weeks during a routine toxicity study. There was a deficiency of lachrymal secretion associated with keratitis and corneal vascularization. Histopathologically, the changes were characterized by vascularization, fibroblast proliferation and infiltration of inflammatory cells in the substantia propria. In some cases, the inflammation also occurred in corneal epithelium, ocular conjunctiva and corneal limbi.
ISSN:	0021-9975 1532-3129
DOI:	10.1016/0021-9975(87)90016-8