CO-Releasing Binuclear Rhodium Complexes as Inhibitors of Nitric Oxide Generation in Stimulated Macrophages

Nontoxic CO-releasing dirhodium complexes act as inhibitors of NO in stimulated macrophage cells, suggesting that novel antiinflammatory treatments could involve the use of these types of binuclear complexes.

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Bibliographische Detailangaben
Veröffentlicht in:	Inorganic chemistry 2013-12, Vol.52 (24), p.13806-13808
Hauptverfasser:	Moragues, María E, Brines, Rita, Terencio, MaCarmen, Sancenón, Félix, Martínez-Máñez, Ramón, Alcaraz, MaJosé
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Biological Assay Carbon Monoxide - chemistry Carbon Monoxide - metabolism Cell Line Coordination Complexes - chemistry Coordination Complexes - pharmacology Humans Macrophages - drug effects Macrophages - metabolism Models, Biological Nitric Oxide - antagonists & inhibitors Rhodium - chemistry Rhodium - pharmacology
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Beschreibung
Zusammenfassung:	Nontoxic CO-releasing dirhodium complexes act as inhibitors of NO in stimulated macrophage cells, suggesting that novel antiinflammatory treatments could involve the use of these types of binuclear complexes.
ISSN:	0020-1669 1520-510X
DOI:	10.1021/ic401967g