Protamine sulfate-nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells

We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)-nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and ΔNp63, exhibiting a gr...

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Veröffentlicht in:	Nanoscale 2013-01, Vol.5 (24), p.12120-12125
Hauptverfasser:	Cao, Minjun, Deng, Xiongwei, Su, Shishuai, Zhang, Fang, Xiao, Xiangqian, Hu, Qin, Fu, Yongwei, Yang, Burton B, Wu, Yan, Sheng, Wang, Zeng, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cell Line, Tumor Drug Carriers - chemistry Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Gene Expression Regulation, Neoplastic Gene Transfer Techniques Genetic Therapy - methods Humans MicroRNAs - genetics Nanodiamonds - chemistry Nanodiamonds - therapeutic use Nanoparticles - chemistry Nanoparticles - therapeutic use Protamines - chemistry Protamines - therapeutic use RNA, Small Interfering - administration & dosage
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Zusammenfassung:	We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)-nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and ΔNp63, exhibiting a great potential for PS@ND nanoparticles in miRNA-based cancer therapy.
ISSN:	2040-3364 2040-3372
DOI:	10.1039/c3nr04056a