Copper-catalyzed synthesis of 1,2,4-trisubstituted pyrroles viacascade reactions of aryloxy-enynes with amines

Copper-catalyzed synthesis of 1,2,4-trisubstituted pyrroles viacascade reactions of aryloxy-enynes with amines

A highly efficient copper-catalyzed cascade reaction of aryloxy-enynes with amines under mild reaction conditions has been developed. This methodology offers rapid access to 1,2,4-trisubstituted pyrroles in good to excellent yields in a regioselective manner.

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Veröffentlicht in:RSC advances 2013-10, Vol.3 (45), p.22872-22876
Hauptverfasser: Li, Ende, Cheng, Xingcan, Wang, Chengyu, Sun, Xia, Li, Yanzhong
Format: Artikel
Sprache:eng
Schlagworte:
Amines
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Zusammenfassung:A highly efficient copper-catalyzed cascade reaction of aryloxy-enynes with amines under mild reaction conditions has been developed. This methodology offers rapid access to 1,2,4-trisubstituted pyrroles in good to excellent yields in a regioselective manner.
ISSN:2046-2069
DOI:10.1039/c3ra44595j