Blockage of the fast sodium current by dimetindene in frog auricular fibres

Blockage of the fast sodium current by dimetindene in frog auricular fibres

The effect of dimetindene (DMI) on action potential and fast inward Na current (I sub(Na)) of frog atrial fibres was studied. DMI reduced the amplitude and maximum rate of rise of the action potentials without altering the resting membrane potential. The drug inhibited the fast Na conductance in a c...

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Veröffentlicht in:Naunyn-Schmiedeberg's archives of pharmacology 1987-03, Vol.335 (3), p.321-325
Hauptverfasser: MESZAROS, J, MARKO, R, KELEMEN, K, KECSKEMETI, V
Format: Artikel
Sprache:eng
Schlagworte:
Antiarythmic agents
atrium
Biological and medical sciences
Cardiovascular system
dimetindene
Medical sciences
Pharmacology. Drug treatments
Rana
sodium
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Zusammenfassung:The effect of dimetindene (DMI) on action potential and fast inward Na current (I sub(Na)) of frog atrial fibres was studied. DMI reduced the amplitude and maximum rate of rise of the action potentials without altering the resting membrane potential. The drug inhibited the fast Na conductance in a concentration-dependent manner, without changing the reversal potential. The results suggest that DMI interacts with the inactivation mechanism of the sodium channel of the frog myocardium, and explain its favourable antiarrhythmic activity.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00172804