Hepatocyte culture as a model system for the study of hepatotoxicity

Hepatocyte culture as a model system for the study of hepatotoxicity

Isolated rat hepatocytes were used to study halothane hepatotoxicity. Halothane impairs the energy status of isolated hepatocytes, an effect that is probably due to the anaesthetic itself and not to a metabolite. Lipid peroxidation and a decrease in the cytochrome P-450 level are only observed in ce...

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Veröffentlicht in:Food and chemical toxicology 1986, Vol.24 (6), p.569-570
Hauptverfasser: van Iersel, A.A.J., de Boer, A.J., van Holsteijn, C.W.M., Blaauboer, B.J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Isolated rat hepatocytes were used to study halothane hepatotoxicity. Halothane impairs the energy status of isolated hepatocytes, an effect that is probably due to the anaesthetic itself and not to a metabolite. Lipid peroxidation and a decrease in the cytochrome P-450 level are only observed in cells from phenobarbitone-pretreated rats and are dependent on the oxygen concentration under which the cells are cultured. These effects are probably caused by a metabolite.
ISSN:0278-6915
1873-6351
DOI:10.1016/0278-6915(86)90116-X