Permeability of isolated hepatocytes and impermeability of cultured hepatocytes and liver slices to EDTA

Permeability of isolated hepatocytes and impermeability of cultured hepatocytes and liver slices to EDTA

The calcium salt of ethylene-diaminetetraacetic acid (EDTA) at a concentration of 4 mM can prevent the toxicity exhibited by paracetamol in suspensions of isolated hepatocytes and one of its benefits is a reduction in the degree of lipid peroxidation. However, the authors report here on the inabilit...

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Veröffentlicht in:Food and chemical toxicology 1986, Vol.24 (6), p.801-802
Hauptverfasser: Hue, D.P., Beales, D., Griffith, K.L., McLean, A.E.M.
Format: Artikel
Sprache:eng
Schlagworte:
cell culture
cell permeability
EDTA
hepatocytes
liver
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Zusammenfassung:The calcium salt of ethylene-diaminetetraacetic acid (EDTA) at a concentration of 4 mM can prevent the toxicity exhibited by paracetamol in suspensions of isolated hepatocytes and one of its benefits is a reduction in the degree of lipid peroxidation. However, the authors report here on the inability of CaEDTA to protect against paracetamol injury in other in vitro systems and relate this to the impermeability of these models to CaEDTA.
ISSN:0278-6915
1873-6351
DOI:10.1016/0278-6915(86)90190-0