Association of Neuroimmune Guidance Cue Netrin-1 and Its Chemorepulsive Receptor UNC5B With Atherosclerotic Plaque Expression Signatures and Stability in Human(s): Tampere Vascular Study (TVS)

Association of Neuroimmune Guidance Cue Netrin-1 and Its Chemorepulsive Receptor UNC5B With Atherosclerotic Plaque Expression Signatures and Stability in Human(s): Tampere Vascular Study (TVS)

BACKGROUND—Macrophage (MΦ) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MΦ trafficking and SMC activation. Characterization of expression of NTN1 and its r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Circulation. Cardiovascular genetics 2013-12, Vol.6 (6), p.579-587
Hauptverfasser: Oksala, Niku, Pärssinen, Jenita, Seppälä, Ilkka, Raitoharju, Emma, Ivana, Kholova, Hernesniemi, Jussi, Lyytikäinen, Leo-Pekka, Levula, Mari, Mäkelä, Kari-Matti, Sioris, Thanos, Kähönen, Mika, Laaksonen, Reijo, Hytönen, Vesa, Lehtimäki, Terho
Format: Artikel
Sprache:eng
Schlagworte:
Actins - genetics
Actins - metabolism
Aged
Aged, 80 and over
Cluster Analysis
Down-Regulation
Female
Gene Expression Profiling
Humans
Inflammation - genetics
Inflammation - metabolism
Macrophages - metabolism
Male
Microscopy, Confocal
Middle Aged
Monocytes - metabolism
Myocytes, Smooth Muscle - metabolism
Nerve Growth Factors - genetics
Nerve Growth Factors - metabolism
Netrin-1
Oligonucleotide Array Sequence Analysis
Plaque, Atherosclerotic - genetics
Plaque, Atherosclerotic - metabolism
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Up-Regulation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:BACKGROUND—Macrophage (MΦ) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MΦ trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. METHODS AND RESULTS—The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (−2.9-fold; P
ISSN:1942-325X
1942-3268
DOI:10.1161/CIRCGENETICS.113.000141