Inhibition by indomethacin and 5,8,11,14-eicosatetraynoic acid of the induction of rat hepatic ornithine decarboxylase by the tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in vivo

The involvement of arachidonate metabolism in the induction of rat hepatic ornithine decarboxylase (ODC) activity by the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) was investigated. Pretreatment of the rats with indomethacin or 5,8,11,14-eicosateraynoic acid do...

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Veröffentlicht in:	Carcinogenesis (New York) 1987-01, Vol.8 (1), p.191-192
Hauptverfasser:	van Rooijen, Lucio A.A., Uijtewaal, Brenda, Bisschop, Arnold
Format:	Artikel
Sprache:	eng
Schlagworte:	5,8,11,14-Eicosatetraynoic Acid - pharmacology Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Drug Interactions Enzyme Induction Fatty Acids, Unsaturated - pharmacology Female Indomethacin - pharmacology Liver - enzymology Medical sciences Ornithine Decarboxylase - biosynthesis Phenobarbital - pharmacology Rats Tetradecanoylphorbol Acetate - pharmacology Tumors
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Zusammenfassung:	The involvement of arachidonate metabolism in the induction of rat hepatic ornithine decarboxylase (ODC) activity by the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) was investigated. Pretreatment of the rats with indomethacin or 5,8,11,14-eicosateraynoic acid dose dependently inhibited the induction of ODC by both tumor promoters. Both inhibitors were more potent inhibitors of PB induction than TPA induction of ODC. The data are consistent with an involvement of arachidonate cyclooxygenase products in the induction of rat hepatic ODC by the tumor promoters.
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/8.1.191