Prognostic value of EZH2, paxillin expression and DNA ploidy of breast adenocarcinoma: correlation to pathologic predictors

Prognostic value of EZH2, paxillin expression and DNA ploidy of breast adenocarcinoma: correlation to pathologic predictors

The objective of this study was to examine the association of EZH2 and paxillin expression and DNA ploidy status with pathological parameters of breast cancer, aiming to correlate tumor phenotype with its malignant behavior. EZH2 and paxillin expression and DNA ploidy were evaluated in imprint smear...

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Veröffentlicht in:Journal of B.U. ON. 2013-10, Vol.18 (4), p.879-885
Hauptverfasser: Panousis, D, Xepapadakis, G, Lagoudianakis, E, Karavitis, G, Salemis, N, Koronakis, N, Patsouris, E, Koronarchis, D, Grosomanidis, D, Chryssikos, G, Ntasiou, P, Kyriakidou, V, Athanassiadou, A M, Athanassiadou, P
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers, Tumor - analysis
Breast Neoplasms - chemistry
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - chemistry
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - pathology
Carcinoma, Lobular - chemistry
Carcinoma, Lobular - genetics
Carcinoma, Lobular - pathology
Cell Differentiation
Chi-Square Distribution
Enhancer of Zeste Homolog 2 Protein
Female
Humans
Logistic Models
Lymphatic Metastasis
Multivariate Analysis
Neoplasm Grading
Neoplasm Staging
Paxillin - analysis
Phenotype
Ploidies
Polycomb Repressive Complex 2 - analysis
Prognosis
Risk Factors
Tumor Burden
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Zusammenfassung:The objective of this study was to examine the association of EZH2 and paxillin expression and DNA ploidy status with pathological parameters of breast cancer, aiming to correlate tumor phenotype with its malignant behavior. EZH2 and paxillin expression and DNA ploidy were evaluated in imprint smear samples obtained from 105 breast tumors after surgical removal. Increased expression of paxillin was associated with p53 expression (p=0.005), Ki-67 expression (p=0.018) and EZH2 expression (p
ISSN:1107-0625