Lack of association of Lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a south Indian population
Intracranial aneurysm (IA) accounts for 85 % of haemorrhagic stroke and is mainly caused due to weakening of arterial wall. Lysyl oxidase (LOX) is a cuproenzyme involved in cross linking structural proteins collagen and elastin, thus providing structural stability to artery. Using a case–control stu...
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Veröffentlicht in: | Molecular biology reports 2013-10, Vol.40 (10), p.5869-5874 |
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Zusammenfassung: | Intracranial aneurysm (IA) accounts for 85 % of haemorrhagic stroke and is mainly caused due to weakening of arterial wall. Lysyl oxidase (LOX) is a cuproenzyme involved in cross linking structural proteins collagen and elastin, thus providing structural stability to artery. Using a case–control study design, we tested the hypothesis whether the variants in
LOX
gene flanking the two LD block, can increase risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. SNPs were genotyped by fluorescence-based competitive allele-specific PCR (KASPar) chemistry. We selected 200 radiologically confirmed aneurysmal cases and 235 ethnically and age and gender matched controls from the Dravidian Malayalam speaking population of South India. We observed marked interethnic differences in the genotype distribution of
LOX
variants when compared to Japanese and African populations. However, there was no significant association with any of the
LOX
variants with IA. This study also could not observe any significant role of
LOX
polymorphisms in influencing IA either directly or indirectly through its confounding factors such as hypertension and gender in South Indian population. |
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ISSN: | 0301-4851 1573-4978 |
DOI: | 10.1007/s11033-013-2693-1 |