Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists
A novel series of aminomethyl substituted thieno[2,3-d]pyrimidines have been identified as adenosine A2A receptor antagonists. Analogues show excellent in vitro activities and have excellent activity in vivo in mouse models of Parkinson's disease.
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| Veröffentlicht in: | MedChemComm 2011, Vol.2 (10), p.950-965 |
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| container_title | MedChemComm |
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| creator | Shook, Brian C. Charavarty, Devraj Barbay, J. Kent Wang, Aihua Leonard, Kristi Alford, Vernon Powell, Mark Beauchamp, Derek A. Rassnick, Stefanie Scannevin, Robert Carroll, Karen Wallace, Nathaniel Crooke, Jeffrey Ault, Mark Lampron, Lisa Westover, Lori Rhodes, Kenneth Jackson, Paul F. |
| description | A novel series of aminomethyl substituted thieno[2,3-d]pyrimidines have been identified as adenosine A2A receptor antagonists. Analogues show excellent in vitro activities and have excellent activity in vivo in mouse models of Parkinson's disease. |
| doi_str_mv | 10.1039/c1md00082a |
| format | Article |
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| ispartof | MedChemComm, 2011, Vol.2 (10), p.950-965 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| title | Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists |
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